[Methylprednisolone- acute spinal cord injury, benefits or risks?].
نویسندگان
چکیده
Methylprednisolone is a synthetic glucocorticoid with a potent and long-acting anti-inflammatory, antiallergic and immunosuppressant. Its mechanism of action of methylprednisolone is the result of many cellular changes. Methylprednisolone is used in many diseases, such as rheumatic diseases, autoimmune diseases, allergic, anaphylactic shock, asthma. Methylprednisolone was also used in patients with spinal cord injury, in order to minimize neurological damage. While in the above mentioned fields of medicine is undeniable role of methylprednisolone, whereas its use in the treatment of traumatic spinal cord injury within the last few years raises a lot of controversy, and in most cases, the side effects of its use outweigh the potential benefits.
منابع مشابه
A Comparison between Therapeutic Effect of Granulocyte Colony-stimulating Factor and Methylprednisolone in Treatment of Patients with Acute Traumatic Spinal Cord Injury
Background & Aim: Spinal cord injury (SCI) is one of the worst kinds of traumatic injuries with remarkable social and economic effects on communities. Methods & Materials/Patients: In this prospective randomized clinical trial, 122 patients with traumatic spinal cord injury were admitted to Poursina hospital within 48 hours of injury to compare granulocyte colony stimulating factor (G-...
متن کاملاثر متیل پردنیزولون بر ضربالعجل درمانی هیپوترمی سیستمیک در درمان ضایعه تروماتیک تجربی خفیف نخاع در رت
Background and Aim: Many studies have shown the neuroprotective effect of systemic hypothermia in the treatment of spinal cord injury. But the effect of delay hypothermia is not known.The goal of this study was to evaluate the effects of Methylprednisolone on the therapeutic window of hypothermia treatment following experimental Spinal Cord Injury (SCI) by measuring the accumulation of Poly...
متن کاملAcute traumatic spinal cord injury, 1993-2000A population-based assessment of methylprednisolone administration and hospitalization.
BACKGROUND Administration of methylprednisolone sodium succinate (MPSS) after acute traumatic spinal cord injury (TSCI) is controversial. This study compared differences in acute care charge, hospital stay, and related variables as a function of MPSS receipt. METHODS Determinants of MPSS administration were examined after acute TSCI for South Carolina patients during the period 1993 to 2000 i...
متن کاملThe administration of a methylprednisolone infusion
following acute spinal cord injury was widely adopted following the report of the results of the second national acute spinal cord injury study in 1990.1 Subsequent clinical studies and critical reviews of the study methodology and results have challenged the validity of the initial conclusions.2-11 Therefore, a current systematic review was conducted to provide evidence-based ABSTRACT: Backgro...
متن کاملEffect of Intravenous Injection of Erythropoietinon Hospitalization Period in Patients with Acute Spinal Cord Trauma
Background & Aim: Spinal cord injury (SCI) has a very long history, and its cases form a large proportion of patients admitted to trauma centers in Iran. Studies show that repair after spinal cord injury can be done. In fact, many pharmaceutical agents, such as erythropoietin (EPO), are applied to reduce secondary injury following the initial disorder and to maintain the nerve tissue. Methods &...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Postepy higieny i medycyny doswiadczalnej
دوره 67 شماره
صفحات -
تاریخ انتشار 2013